Elucidation of urinary extracellular vesicle protein signatures from patients with cribriform and intraductal prostate carcinoma

ABSTRACT: A comprehensive systemic assessment of the proteome changes that occur in prostate cancer (PCa) during the onset and course of the illness may produce results that are clinically significant. Proteins, the main participants in the majority of biological events, are both potential biomarkers and therapeutic targets. Although the PCa tissue proteome has already been described, screening tissue samples is an intrusive operation. As a result, we concentrated on liquid biopsies like urine samples for this investigation. Specifically, liquid chromatography coupled to high-resolution mass spectrometry (LC-MS/MS) was employed to examine the urinary small extracellular vesicle (EV) proteome patterns of 100 patients. The main objective of this study is to identify biomarkers for PCa patients with cribriform pattern and intraductal PCa (IDC).

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Urine, Extracellular Exosome

DISEASE(S): Prostate Adenocarcinoma

SUBMITTER: Rune Matthiesen  

LAB HEAD: Rune Matthiesen

PROVIDER: PXD043874 | Pride | 2025-05-06

REPOSITORIES: Pride