Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive Plus
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Fibroblast
DISEASE(S): Pulmonary Hypertension
SUBMITTER: Francesco Pagano
LAB HEAD: Jamila H Siamwala
PROVIDER: PXD044147 | Pride | 2024-01-26
REPOSITORIES: Pride
Siamwala Jamila H JH Pagano Francesco S FS Dubielecka Patrycja M PM Ivey Malina J MJ Guirao-Abad Jose Pedro JP Zhao Alexander A Chen Sonja S Granston Haley H Jeong Jae Yun JY Rounds Sharon S Kanisicak Onur O Sadayappan Sakthivel S Gilbert Richard J RJ
Communications biology 20231125 1
The source and roles of fibroblasts and T-cells during maladaptive remodeling and myocardial fibrosis in the setting of pulmonary arterial hypertension (PAH) have been long debated. We demonstrate, using single-cell mass cytometry, a subpopulation of endogenous human cardiac fibroblasts expressing increased levels of CD4, a helper T-cell marker, in addition to myofibroblast markers distributed in human fibrotic RV tissue, interstitial and perivascular lesions in SUGEN/Hypoxia (SuHx) rats, and fi ...[more]