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Citrullinated proteins in monocyte organelle fractions

ABSTRACT: Citrullinated proteins found in the organelle fractions of monocytes incubated in calcium

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Monocyte, Blood

SUBMITTER: Mekha Thomas

LAB HEAD: Erika Darrah

PROVIDER: PXD044188 | Pride | 2023-10-03

REPOSITORIES: Pride

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An unbiased proteomic analysis of PAD4 in human monocytes: novel substrates, binding partners and subcellular localizations.

Thomas Mekha A MA Kim Seok-Young SY Curran Ashley M AM Smith Barbara B Antiochos Brendan B Na Chan Hyun CH Darrah Erika E

Philosophical transactions of the Royal Society of London. Series B, Biological sciences 20231002 1890

Peptidylarginine deiminase IV (PAD4) post-translationally converts arginine residues in proteins to citrullines and is implicated in playing a central role in the pathogenesis of several diseases. Although PAD4 was historically thought to be a nuclear enzyme, recent evidence has revealed a more complex localization of PAD4 with evidence of additional cytosolic and cell surface localization and activity. However, the mechanisms by which PAD4, which lacks conventional secretory signal sequences, t ...[more]

PMID: 37778379

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