Proteomics

Dataset Information

0

The microenvironment dictates glyco-immune surveillance via HSF1-mediated metabolism


ABSTRACT: Efforts to identify anti-cancer therapeutics are attempted with in vitro models that do not match the microenvironmental characteristics of human tissues. Using biocompatible hydrogels that mimic healthy or cancerous tissues and conventional or physiologically relevant culture medium, we systematically demonstrate that the chemical and physical properties of the microenvironment regulate the composition and topology of the glycocalyx, a pericellular matrix composed of carbohydrate-conjugates. Remarkably, we find that cancer and age-related changes in the physical properties of the microenvironment are sufficient to adjust immune surveillance via the topology of the glycocalyx, a previously unknown phenomenon observable only with physiologically relevant culture medium.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Alicia Richards  

LAB HEAD: Danielle L

PROVIDER: PXD044309 | Pride | 2026-04-10

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
Raw.7z Other
accumulatedMsmsScans.txt Txt
allPeptides.txt Txt
evidence.txt Txt
modificationSpecificPeptides.txt Txt
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