Identification of a direct interaction between the Fab domains of IgG antibodies and human FcRn upon IgG-FcRn complex formation

ABSTRACT: Chemical cross-linking coupled to mass spectrometry was used to study the interaction between IgG-type antibodies and the neonatal Fc receptor (FcRn). Different cross-linking chemistries were used, including disuccinimidyl suberate (DSS); a combination of pimelic dihydrazide (PDH) in combination with the zero-length cross-linking reagent, DMTMM; and the Xplex method using hexanediamine and N-hydroxybenzotriazole.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Alexander Leitner  

LAB HEAD: Alexander Leitner

PROVIDER: PXD044405 | Pride | 2024-12-03

REPOSITORIES: Pride