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The screening of cross-reactive targets of recombinant anti-collagen antibody R69-4

ABSTRACT: Rheumatoid arthritis (RA) is an autoimmune disease affecting approximately 0.5% of the global population. Despite its prevalence, there is no known cure, underscoring the persistent need for novel therapeutic strategies. In previous studies, we identified a specific subset of antibodies that target an epitope (F4) on type-II collagen (COL2), which seemed to offer protection against arthritis. Leveraging these findings, we have engineered a range of recombinant antibodies against this epitope. Notably, one such antibody, R69-4, has shown significant potential in suppressing arthritis. Here, we aim to identify potential cross-reactive targets of R69-4 to better understand its mechanism of action.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Synovial Fluid, Blood Serum

DISEASE(S): Rheumatoid Arthritis

SUBMITTER: Susanna Lundström

LAB HEAD: Roman Zubarev

PROVIDER: PXD044700 | Pride | 2023-09-05

REPOSITORIES: Pride

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