Conformational plasticity of RAS Q61 family of neoepitopes results in distinct features for targeted recognition.
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ABSTRACT: We utilize hydrogen deuterium exchange mass spectrometry (HDX-MS) to probe the solvation and conformational dynamics of HLA-A*01:01/hβ2m complexes that are emptied or loaded with NRAS Q61K peptide, as well as wild-type (Q61) and three additional, common neoepitopes (Q61H, Q61L, Q61R).
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Yi Sun
LAB HEAD: Nikolaos Sgourakis
PROVIDER: PXD044838 | Pride | 2023-11-30
REPOSITORIES: Pride
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