Proteomics

Dataset Information

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Conformational plasticity of RAS Q61 family of neoepitopes results in distinct features for targeted recognition.


ABSTRACT: We utilize hydrogen deuterium exchange mass spectrometry (HDX-MS) to probe the solvation and conformational dynamics of HLA-A*01:01/hβ2m complexes that are emptied or loaded with NRAS Q61K peptide, as well as wild-type (Q61) and three additional, common neoepitopes (Q61H, Q61L, Q61R).

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Yi Sun  

LAB HEAD: Nikolaos Sgourakis

PROVIDER: PXD044838 | Pride | 2023-11-30

REPOSITORIES: Pride

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