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Cryo-EM study of human liver mitochondria lysate

ABSTRACT: This is the proteomic analysis data of Human liver mitochondria lysate subjected to cryo-EM study.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Liver

SUBMITTER: zhemin zhang

LAB HEAD: Edward W

PROVIDER: PXD044860 | Pride | 2024-01-26

REPOSITORIES: Pride

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High-Resolution Structural Proteomics of Mitochondria Using the 'Build and Retrieve' Methodology.

Zhang Zhemin Z Tringides Marios L ML Morgan Christopher E CE Miyagi Masaru M Mears Jason A JA Hoppel Charles L CL Yu Edward W EW

Molecular & cellular proteomics : MCP 20231014 12

The application of integrated systems biology to the field of structural biology is a promising new direction, although it is still in the infant stages of development. Here we report the use of single particle cryo-EM to identify multiple proteins from three enriched heterogeneous fractions prepared from human liver mitochondrial lysate. We simultaneously identify and solve high-resolution structures of nine essential mitochondrial enzymes with key metabolic functions, including fatty acid cata ...[more]

PMID: 37839702

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