Proteomic analysis of Methylomonas DH-1 AlaRS mutant versus wildtype
Ontology highlight
ABSTRACT:
INSTRUMENT(S):
ORGANISM(S): Methylomonas Sp.
SUBMITTER: 
Changmin Sung
LAB HEAD: Changmin Sung
PROVIDER: PXD044904 | Pride | 2026-02-09
REPOSITORIES: Pride
Dataset's files
Publications
Unlocking the serine mischarging paradox and inhibiting lactyltransferase activity of AlaRS by a single-point mutation.
Park Wooyoung W Son Se-Young SY Yi Joonyeop J Cha Seungwoo S Moon Hankyeol H Kim Minyoung M Ji Sangho S Yu Wookyung W Sung Changmin C Cha Sun-Shin SS Hahn Ji-Sook JS
Nucleic acids research 20250601 11
Aminoacyl-tRNA synthetases are critical for accurate genetic translation, attaching amino acids to their corresponding transfer RNA molecules. Alanyl-tRNA synthetase (AlaRS) often misactivates Ser or Gly instead of Ala, which is detrimental unless corrected by its editing functions. The paradox of misactivating larger Ser by AlaRS was considered inevitable due to its inherent design, sharing an essential acidic residue to accommodate the activated adenylated intermediates from both cognate and n ...[more]
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