0N4R Tau and 0N4R Tau P301L Neuronal Interactomes

ABSTRACT: Human non-mutated 0N4R Tau and P301L mutant 0N4R Tau tagged at the N-terminus with eGFP were expressed in mouse (CD1) primary cortical neurons using adeno associated viruses to monitor early changes in the synaptic interactome beforethe onset of neuronal loss. Affinity purification mass spectrometry (AP-MS) combined with tandem mass tagging was used to quantitatively compate the non-mutated and P301L interactomes.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Primary Neuron, Cell Culture

DISEASE(S): Frontotemporal Dementia

SUBMITTER: Robert Williams  

LAB HEAD: Robert Justin Williams

PROVIDER: PXD044959 | Pride | 2024-07-03

REPOSITORIES: Pride