Diversity of post-translational modifications and signaling networks revealed by single cell and organelle mass spectrometry

ABSTRACT: Using an optimized data-independent acquisition approach on trapped ion mobility spectrometry, we measured proteins, post-translational modifications and variant peptides in single cells and single nuclei, which provided insights into heterogeneity of cell-state and signaling dependencies at the single cell level and the molecular impact of an epigenetic drug at the level of a single organelle.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cholangiocyte, T Cell

SUBMITTER: Akhilesh Pandey  

LAB HEAD: Akhilesh Pandey

PROVIDER: PXD044986 | Pride | 2024-08-02

REPOSITORIES: Pride