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Proteome-wide discovery of human brain protein glycoforms and glycan modification changes in Alzheimer’s disease

ABSTRACT: We performed a large-scale, intact glycopeptide-based glycoproteomics study of human brain tissue samples from neuropathologically confirmed AD cases and their age-matched controls. The study provided a system-level view of human brain protein glycoforms and site-specific glycan modifications. Our analyses revealed previously unknown changes in protein glycoforms and site-specific glycans in AD brain. Our findings provide novel insights into the roles of glycan modifications in brain dysfunction in AD.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Brain

DISEASE(S): Alzheimer's Disease

SUBMITTER: QI ZHANG

LAB HEAD: Lian Li

PROVIDER: PXD045001 | Pride | 2024-04-08

REPOSITORIES: Pride

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