TGM1 interaction partners identification reveals possible TGM1 posttranslational modifiers
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: 
Marta Surbek
LAB HEAD: dr. Leopold
PROVIDER: PXD045105 | Pride | 2024-01-26
REPOSITORIES: Pride
Publications
Cornification of keratinocytes is associated with differential changes in the catalytic activity and the immunoreactivity of transglutaminase-1.
Surbek Marta M Van de Steene Tessa T Sachslehner Attila Placido AP Golabi Bahar B Griss Johannes J Eyckerman Sven S Gevaert Kris K Eckhart Leopold L
Scientific reports 20231206 1
Transglutaminase 1 (TGM1) plays an essential role in skin barrier formation by cross-linking proteins in differentiated keratinocytes. Here, we established a protocol for the antibody-dependent detection of TGM1 protein and the parallel detection of TGM activity. TGM1 immunoreactivity initially increased and co-localized with membrane-associated TGM activity during keratinocyte differentiation. TGM activity persisted upon further differentiation of keratinocytes, whereas TGM1 immunoreactivity wa ...[more]
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Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
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