Impact of anesthetics on rat hippocampus and neocortex: a comprehensive proteomic study based on label-free mass spectrometry

ABSTRACT: In this work, in vivo experiment simulating a general anesthesia and ICU sedation was designed to assess the impact of two intravenous (midazolam, dexmedetomidine) and two inhalational (isoflurane, desflurane) agents to neuronal centers for cognition (neocortex), learning, and memory (hippocampus). More than 3600 proteins were quantified across both neocortex and hippocampus. Proteomic study revealed relatively mild effects of anesthetics, nevertheless, protein dysregulation uncovered possible different effect of isoflurane (and midazolam) compared to desflurane (and dexmedetomidine) to neocortical and hippocampal proteins.

INSTRUMENT(S):

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Brain

SUBMITTER: Marie Vajrychová  

LAB HEAD: Marie Vajrychova

PROVIDER: PXD045159 | Pride | 2024-05-23

REPOSITORIES: Pride