Proteomics

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Antiangiogenic Potential of an Olive Oil Extract: Insights from a Proteomic Study

ABSTRACT: In this comprehensive study, we delve into the examination of the phenolic fraction found in Extra Virgin Olive Oils (EVOOs) and its potential impact on endothelial cells, with a particular focus on its role in angiogenesis. To accomplish this, we employed a phenolic extract derived from EVOO sourced from the Picual variety in Jaén, Spain. Our investigation of an extract offers a compelling advantage, enabling us to obtain larger quantities of bioactive molecules compared to conventional dietary consumption, provided that the concentrations of these diverse compounds within the mixture are deemed safe. Furthermore, this approach permits us to meticulously isolate and assess the effects of these molecules independently from the other components of EVOO, such as fatty acids and more.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Cell Culture

SUBMITTER: Casimiro Cardenas  

LAB HEAD: Miguel Angel Medina

PROVIDER: PXD045447 | Pride | 2024-01-26

REPOSITORIES: Pride

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Publications

New insights in the targets of action of dimethyl fumarate in endothelial cells: effects on energetic metabolism and serine synthesis in vitro and in vivo.

Ocaña Mª Carmen MC   Bernal Manuel M   Yang Chendong C   Caro Carlos C   Domínguez Alejandro A   Vu Hieu S HS   Cárdenas Casimiro C   García-Martín María Luisa ML   DeBerardinis Ralph J RJ   Quesada Ana R AR   Martínez-Poveda Beatriz B   Medina Miguel Ángel MÁ  

Communications biology 20231025 1

Dimethyl fumarate is an ester from the Krebs cycle intermediate fumarate. This drug is approved and currently used for the treatment of psoriasis and multiple sclerosis, and its anti-angiogenic activity was reported some years ago. Due to the current clinical relevance of this compound and the recently manifested importance of endothelial cell metabolism on the angiogenic switch, we wanted to elucidate whether dimethyl fumarate has an effect on energetic metabolism of endothelial cells. Differen  ...[more]

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