Name: SIRT2 interactomics in HeLa cells
Keywords: Sirt2

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SIRT2 interactomics in HeLa cells

ABSTRACT: We aim to discovery new interactors of the deacetylase, SIRT2 from HeLa cells.

INSTRUMENT(S): Orbitrap Exploris 480

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: Yutong Li

LAB HEAD: Jianyuan Luo

PROVIDER: PXD045456 | Pride | 2023-12-05

REPOSITORIES: Pride

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SIRT2 negatively regulates the cGAS-STING pathway by deacetylating G3BP1.

Li Yutong Y Bie Juntao J Song Chen C Li Yunfei Y Zhang Tianzhuo T Li Haishuang H Zhao Long L You Fuping F Luo Jianyuan J

EMBO reports 20231023 12

SIRT2, a cytoplasmic member of the Sirtuin family, has important roles in immunity and inflammation. However, its function in regulating the response to DNA virus infection remains elusive. Here, we find that SIRT2 is a unique regulator among the Sirtuin family that negatively modulates the cGAS-STING-signaling pathway. SIRT2 is down-regulated after Herpes simplex virus-1 (HSV-1) infection, and SIRT2 deficiency markedly elevates the expression levels of type I interferon (IFN). SIRT2 inhibits th ...[more]

PMID: 37870259

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