Branched N-glycan of PD-L1 predicts immunotherapy responses in patients with recurrent/metastatic HNSCC

ABSTRACT: Immunotherapy has revolutionized cancer treatment, however, a reliable biomarker is missing. MGAT5-mediated PD-L1 glycosylation is critical for its interaction with PD-1. MGAT5 expression is a functional biomarker that predicts immunotherapy responses.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell

DISEASE(S): Oral Squamous Cell Carcinoma

SUBMITTER: Hsin-Yi Wu  

LAB HEAD: Min-Chuan Huang

PROVIDER: PXD045506 | Pride | 2025-05-06

REPOSITORIES: Pride