Ola1p trafficking indicates an interaction network between mitochondria, Lipid droplets and stress granules in times of stress

ABSTRACT: Protein aggregates arise naturally under normal physiological conditions, but their formation is accelerated by age or stress-induced protein misfolding. One of the proteins that accumulate upon stress in yeast cells is Ola1p, know as the “super aggregator” Using a proximity labelling approach based upon the biotin ligase TurboID we were able to show that these Ola1p harbouring aggregates are, in fact, stress granules that interact with both mitochondria and LDs.

INSTRUMENT(S):

ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast)

SUBMITTER: Peter Briza  

LAB HEAD: Peter Briza

PROVIDER: PXD045513 | Pride | 2024-01-26

REPOSITORIES: Pride