Proteomics

Dataset Information

0

Lachesis muta snake venom peptidome

ABSTRACT: Snake venoms are known to be major sources of peptides with different pharmacological properties. In this study, we comprehensively explored the venom peptidomes of three specimens of Lachesis muta, the largest venomous snake in South America, using mass spectrometry techniques. The analysis revealed 19 main chromatographic peaks common to all specimens. A total of 151 peptides were identified, including 69 from a metalloproteinase, 58 from the BPP-CNP precursor, and 24 from a L-amino acid oxidase. To our knowledge, 126 of these peptides were reported for the first time in this work, including a new SVMP-derived peptide fragment, Lm-10a. Our findings highlight the dynamic nature of toxin maturation in snake venoms, driven by proteolytic processing, post-translational modifications, and cryptide formation.

INSTRUMENT(S): Synapt MS

ORGANISM(S): Lachesis Muta

TISSUE(S): Venom

SUBMITTER: Alexandre Keiji Tashima  

LAB HEAD: Alexandre Keiji Tashima

PROVIDER: PXD045732 | Pride | 2023-10-23

REPOSITORIES: Pride

Json Xml
altmetric image

Publications

Unveiling the peptidome diversity of Lachesismuta snake venom: Discovery of novel fragments of metalloproteinase, l-amino acid oxidase, and bradykinin potentiating peptides.

Ito Lucas T LT   Miyamoto Jackson G JG   Sant'Anna Sávio S SS   Grego Kathleen F KF   Tanaka-Azevedo Anita M AM   Tashima Alexandre K AK  

Biochemical and biophysical research communications 20231006

Snake venoms are known to be major sources of peptides with different pharmacological properties. In this study, we comprehensively explored the venom peptidomes of three specimens of Lachesismuta, the largest venomous snake in South America, using mass spectrometry techniques. The analysis revealed 19 main chromatographic peaks common to all specimens. A total of 151 peptides were identified, including 69 from a metalloproteinase, 58 from the BPP-CNP precursor, and 24 from a l-amino acid oxidas  ...[more]

Similar Datasets

Proteomics A snapshot of Bothrops jararaca snake venom gland subcellular proteome
2023-09-30 | PXD040239 | Pride
Proteomics A novel peptide from Bothrops cotiara peptidome
2023-10-20 | PXD041473 | Pride
Proteomics Venomics reveals an ant venom peptidome
2018-08-29 | PXD010451 | Pride
Proteomics Comparative gender peptidomics of Bothrops atrox venoms: new peptides and evidences of increased disintegrins levels in the venoms of females
2020-10-13 | PXD018632 | Pride
Proteomics A multi-omics approach unravels new toxins with potential antimicrobial, antiviral and antitumoral activities in the venom of Acanthoscurria rondoniae
2020-07-20 | PXD019343 | Pride
Proteomics Hiss of death - Biogeographical venom variation in the Indian spectacled cobra (Naja naja) underscores the pressing need for pan-India efficacious snakebite therapy
2021-02-10 | PXD020497 | Pride
Proteomics Biogeographic venom variation in medically important Indian snakes and the inadequacy of antivenom therapy in snakebite hotspots
2021-02-26 | PXD021060 | Pride
Proteomics Peptidomics analysis of dromedary camel supraoptic nucleus by tandem mass spectrometry
2019-11-11 | PXD013869 | Pride
Proteomics Candida albicans proteomics_biofilm with Aureobasidin treatment
2021-11-25 | PXD007834 | Pride
Proteomics Candida albicans proteomics_planktonic with Aureobasidin treatment
2021-11-25 | PXD007835 | Pride