Proteomics

Dataset Information

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Temporally-resolved proteomic profiling of mouse pancreatic cancer

ABSTRACT: Pancreatic ductal adenocarcinoma (PDAC) is characterized by progressive matrix deposition and fibrosis, which can enhance tumor progression and spread. Here, we undertook an unbiased temporal assessment of the matrix proteome (matrisome) of the highly-metastatic KPC and poorly-metastatic KPflC mouse models of pancreatic cancer using data independent acquisition (DIA) mass spectrometry proteomics.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Pancreatic Cancer Cell

SUBMITTER: Benjamin Parker  

LAB HEAD: Benjamin Parker

PROVIDER: PXD045830 | Pride | 2024-08-10

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
20190106_QEHFX1_TimpsonCox_Pancreas_A1.raw Raw
20190106_QEHFX1_TimpsonCox_Pancreas_A2.raw Raw
20190106_QEHFX1_TimpsonCox_Pancreas_A3.raw Raw
20190106_QEHFX1_TimpsonCox_Pancreas_A4.raw Raw
20190106_QEHFX1_TimpsonCox_Pancreas_A5.raw Raw
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Publications

Temporally resolved proteomics identifies nidogen-2 as a cotarget in pancreatic cancer that modulates fibrosis and therapy response.

Pereira Brooke A BA   Ritchie Shona S   Chambers Cecilia R CR   Gordon Katie A KA   Magenau Astrid A   Murphy Kendelle J KJ   Nobis Max M   Tyma Victoria M VM   Liew Ying Fei YF   Lucas Morghan C MC   Naeini Marjan M MM   Barkauskas Deborah S DS   Chacon-Fajardo Diego D   Howell Anna E AE   Parker Amelia L AL   Warren Sean C SC   Reed Daniel A DA   Lee Victoria V   Metcalf Xanthe L XL   Lee Young Kyung YK   O'Regan Luke P LP   Zhu Jessie J   Trpceski Michael M   Fontaine Angela R M ARM   Stoehr Janett J   Rouet Romain R   Lin Xufeng X   Chitty Jessica L JL   Porazinski Sean S   Wu Sunny Z SZ   Filipe Elysse C EC   Cadell Antonia L AL   Holliday Holly H   Yang Jessica J   Papanicolaou Michael M   Lyons Ruth J RJ   Zaratzian Anaiis A   Tayao Michael M   Da Silva Andrew A   Vennin Claire C   Yin Julia J   Dew Alysha B AB   McMillan Paul J PJ   Goldstein Leonard D LD   Deveson Ira W IW   Croucher David R DR   Samuel Michael S MS   Sim Hao-Wen HW   Batten Marcel M   Chantrill Lorraine L   Grimmond Sean M SM   Gill Anthony J AJ   Samra Jaswinder J   Jeffry Evans Thomas R TR   Sasaki Takako T   Phan Tri G TG   Swarbrick Alexander A   Sansom Owen J OJ   Morton Jennifer P JP   Pajic Marina M   Parker Benjamin L BL   Herrmann David D   Cox Thomas R TR   Timpson Paul P  

Science advances 20240703 27

Pancreatic ductal adenocarcinoma (PDAC) is characterized by increasing fibrosis, which can enhance tumor progression and spread. Here, we undertook an unbiased temporal assessment of the matrisome of the highly metastatic KPC (<i>Pdx1-Cre</i>, <i>LSL-Kras<sup>G12D/+</sup></i>, <i>LSL-Trp53<sup>R172H/+</sup></i>) and poorly metastatic KP<sup>fl</sup>C (<i>Pdx1-Cre</i>, <i>LSL-Kras<sup>G12D/+</sup></i>, <i>Trp53<sup>fl/+</sup></i>) genetically engineered mouse models of pancreatic cancer using mas  ...[more]