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LC-MS/MS proteomic profiling study of ccRCC cell-lines

ABSTRACT: We conducted comparative proteomic analysis with clear cell renal cell carcinoma (ccRCC), a subtype of RCC, have poorer prognosis and metastasize to the lungs, bones and lymph nodes. Comparative proteomic analysis in ccRCC study will reveals novel insights and development of disease.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Kidney

SUBMITTER: Hyunchae Sim

LAB HEAD: Sangkyu Lee

PROVIDER: PXD045898 | Pride | 2025-05-06

REPOSITORIES: Pride

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			Action	DRS
	20220506_SILAC_Kac_Global_RCC_F0-1_3-23.raw	Raw
	20220506_SILAC_Kac_Global_RCC_F0-2_3-23.raw	Raw
	20220506_SILAC_Kac_Global_RCC_F0-3_3-23.raw	Raw
	20220506_SILAC_Kac_Global_RCC_F1-1_3-23.raw	Raw
	20220506_SILAC_Kac_Global_RCC_F1-2_3-23.raw	Raw

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Publications

Comparative Proteomics of ccRCC Cell Lines to Identify Kidney Cancer Progression Factors.

Park Juhee J Sim Hyunchae H Lee Eun Hye EH Kim Bum Soo BS Chung Jae-Wook JW Ha Yun-Sok YS Kwon Tae Gyun TG Lee Sangkyu S Lee Jun Nyung JN

Cancer genomics & proteomics 20241101 6

<h4>Background/aim</h4>Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer, accounting for approximately 75% of kidney cancers. The objective of this study was to identify novel progression markers for ccRCC based on proteomics, with the goal of stage determination and early diagnosis of kidney cancer patients.<h4>Materials and methods</h4>We performed quantitative global proteomics coupled with Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC) and high- ...[more]

PMID: 39467626

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BMAL1-HIF2α heterodimers contribute to ccRCC

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