Proteomics

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Reanalysis of Data-dependent acquisition based proteomic datasets of Mycobacterium abscessus

ABSTRACT: Detection of species-specific proteotypic peptides for accurate and easy characterization of infectious non-tuberculous mycobacteria such as Mycobacterium abscessus is essential. Therefore, we carried out reanalysis of publicly available M. abscessus proteomic dataset MSV000085363, PXD015680 and PXD022644 by proteome database search and followed by spectral library generation. The raw DDA data were searched against the M. abscessus proteome database using Proteome Discoverer and FragPipe. The resulting peptide spectrum matches were converted into a spectral library using BiblioSpec.

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Mycobacterium Abscessus (strain Atcc 19977 / Dsm 44196 / Cip 104536 / Jcm 13569 / Nctc 13031 / Tmc 1543)

SUBMITTER: Keshava Prasad T. S.  

LAB HEAD: Dr T. S. Keshava Prasad

PROVIDER: PXD045930 | Pride | 2024-03-07

REPOSITORIES: Pride

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Discovery of Species-Specific Proteotypic Peptides To Establish a Spectral Library Platform for Identification of Nontuberculosis Mycobacteria from Mass Spectrometry-Based Proteomics.

Kotimoole Chinmaya Narayana CN   Ramya Vadageri Krishnamurthy VK   Kaur Parvinder P   Reiling Norbert N   Shandil Radha Krishan RK   Narayanan Shridhar S   Flo Trude Helen TH   Prasad Thottethodi Subrahmanya Keshava TSK  

Journal of proteome research 20240215 3

Nontuberculous mycobacteria are opportunistic bacteria pulmonary and extra-pulmonary infections in humans that closely resemble <i>Mycobacterium tuberculosis</i>. Although genome sequencing strategies helped determine NTMs, a common assay for the detection of coinfection by multiple NTMs with <i>M. tuberculosis</i> in the primary attempt of diagnosis is still elusive. Such a lack of efficiency leads to delayed therapy, an inappropriate choice of drugs, drug resistance, disease complications, mor  ...[more]

PMID: 38358903

Publication: 1/4

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