Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Eclipse
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
SUBMITTER: Duc Duong
LAB HEAD: Tracy Young-Pearse
PROVIDER: PXD046040 | Pride | 2024-01-26
REPOSITORIES: Pride
Chou Vicky V Pearse Richard V RV Aylward Aimee J AJ Ashour Nancy N Taga Mariko M Terzioglu Gizem G Fujita Masashi M Fancher Seeley B SB Sigalov Alina A Benoit Courtney R CR Lee Hyo H Lam Matti M Seyfried Nicholas T NT Bennett David A DA De Jager Philip L PL Menon Vilas V Young-Pearse Tracy L TL
Nature communications 20231129 1
Microglia and neuroinflammation play an important role in the development and progression of Alzheimer's disease (AD). Inositol polyphosphate-5-phosphatase D (INPP5D/SHIP1) is a myeloid-expressed gene genetically-associated with AD. Through unbiased analyses of RNA and protein profiles in INPP5D-disrupted iPSC-derived human microglia, we find that reduction in INPP5D activity is associated with molecular profiles consistent with disrupted autophagy and inflammasome activation. These findings are ...[more]