A molecular glue degrader of the WIZ transcription factor for fetal hemoglobin induction

ABSTRACT: Here we report the discovery of molecular glue degraders of the WIZ gene control factor that potentially and robustly induce HbF expression in preclinical models.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Erythrocyte

DISEASE(S): Sickle Cell Anemia

SUBMITTER: Amanda Hachey  

LAB HEAD: Amanda Hachey

PROVIDER: PXD046433 | Pride | 2024-07-08

REPOSITORIES: Pride