Proteomics

Dataset Information

0

Sustainability of specific improvements of cardiorespiratory fitness and insulin sensitive metabolism in type 2 diabetes after exercise training

ABSTRACT: High intensity interval training (HIIT) improves metabolism, but maybe with differences in sustainability between prediabetes and type 2 diabetes (T2D). We hypothesized that HIIT-induced changes are maintained after 4-week detraining in humans with (20 T2D) and without T2D (12 insulin-sensitive, IS-NDM; 10 insulin-resistant, IR-NDM). To explore the change in protein cargo of small extracellular vesicles (SEV), we measured the proteome of SEVs from serum of T2D, IR-NMD and IR-NDM individuals.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Serum

DISEASE(S): Type 2 Diabetes Mellitus

SUBMITTER: Polina Lipaeva  

LAB HEAD: Stefan Lehr

PROVIDER: PXD046654 | Pride | 2025-05-06

REPOSITORIES: Pride

Json Xml

Dataset's files

Source:
Action DRS
10112021_E_easy50_2hDIA_34w_Hiitdetraining_IRR_23D_A1484.raw Raw
10112021_E_easy50_2hDIA_34w_Hiitdetraining_IRR_37D_A1485.raw Raw
10112021_E_easy50_2hDIA_34w_Hiitdetraining_IRR_43D_A1486.raw Raw
10112021_E_easy50_2hDIA_34w_Hiitdetraining_IRR_44D_A1487.raw Raw
10112021_E_easy50_2hDIA_34w_Hiitdetraining_IRR_50D_A1488.raw Raw
Items per page:
1 - 5 of 16
altmetric image

Publications

The role of exosomes for sustained specific cardiorespiratory and metabolic improvements in males with type 2 diabetes after detraining.

Mastrototaro Lucia L   Apostolopoulou Maria M   Hartwig Sonja S   Strassburger Klaus K   Lipaeva Polina P   Trinks Nina N   Karusheva Yanislava Y   Gancheva Sofiya S   Trenkamp Sandra S   Lehr Stefan S   Al-Hasani Hadi H   Szendroedi Julia J   Roden Michael M  

EBioMedicine 20241202

<h4>Background</h4>High-intensity interval training (HIIT) has been shown to improve cardiorespiratory fitness (V˙O<sub>2</sub> max) but may ameliorate insulin sensitivity only in insulin-resistant humans. It is yet unclear whether these benefits persist after detraining and to which extent duration and effectiveness of metabolic improvements differ between individuals without and with prediabetes or type 2 diabetes (T2D). Understanding these differences is relevant for developing targeted exerc  ...[more]

Similar Datasets

Proteomics Human adipose tissue proteomics reveal adaptations to exercise and type 2 diabetes
2024-01-10 | PXD040434 | Pride
Proteomics Improving SWATH-MS analysis by Deep-learning
2023-01-16 | PXD038407 | Pride
Proteomics Label-Free Absolute Protein Quantification with Data-Independent Acquisition
2019-03-20 | PXD010912 | Pride
Proteomics Toxicoproteomics reveals an effect of Clozapine on autophagy in human liver spheroids
2022-12-09 | PXD034257 | Pride
Proteomics Advanced mass spectrometry workflows for accurate quantification of trace-level host cell proteins in drug products: benefits of FAIMS separation and gas-phase fractionation DIA
2023-05-07 | PXD039582 | Pride
Proteomics Characterization of Campylobacter jejuni proteome profiles in co-incubation scenarios
2023-11-02 | PXD046477 | Pride
Transcriptomics Transcription profiling of mouse C57BL/6J strain infected with Sendai virus vs. UV irradiated virus to investigate virus-induced airway disease
2008-06-20 | E-GEOD-10964 | biostudies-arrayexpress
Proteomics Toxicoproteomics reveals an effect of Clozapine on autophagy in human liver spheroids
2022-12-13 | PXD038007 | Pride
Transcriptomics Virus-Induced Airway Disease in Mice (C57BL/6J, d49)
2013-08-08 | E-GEOD-49603 | biostudies-arrayexpress
Transcriptomics Virus-Induced Airway Disease in Mice (C57BL/6J, d3)
2015-03-27 | E-GEOD-61437 | biostudies-arrayexpress