Proteomics

Dataset Information

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Identification of dysregulated proteins in primary and relapsed oral cancer tissues with iTRAQ-based mass spectrometry

ABSTRACT: Oral cancer is the sixth leading cause of the cancer-related mortality in Taiwan. More than 90% of oral cancers are oral cavity squamous cell carcinomas (OSCCs). The high mortality rate of OSCC is ascribed to metastasis and local regional relapse of cancer cells, suggesting that identification of proteins involved in migration and chemoresistance of OSCC cells can facilitate development of useful treatment approaches for OSCC. To identify novel targets for improvement of OSCC therapy, we have comparatively profiled the proteomes of primary and relapsed OSCC tissues with iTRAQ-based mass spectrometry. Gene expression of proteins dysregulated in OSCC tissues was further surveyed with the cancer genome atlas (TCGA) database. With the analysis, we have identified proteins differentially expressed in the primary and/or relapsed OSCC tissues. Proteins up-regulated in recurrent OSCC and associated with OSCC survival have been selected for evaluation as potential therapeutic targets of relapsed OSCC.

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Oral Squamous Cell Carcinoma Cell

DISEASE(S): Oral Squamous Cell Carcinoma

SUBMITTER: Chih-Ching Wu  

LAB HEAD: Chih-Ching Wu

PROVIDER: PXD046780 | Pride | 2025-06-04

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
iTRAQ_OSCC29.msf Msf
iTRAQ_OSCC29_1.raw Raw
iTRAQ_OSCC29_10.raw Raw
iTRAQ_OSCC29_11.raw Raw
iTRAQ_OSCC29_12.raw Raw
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Publications

Upregulation of ENAH by a PI3K/AKT/β-catenin cascade promotes oral cancer cell migration and growth via an ITGB5/Src axis.

Chan Xiu-Ya XY   Chang Kai-Ping KP   Yang Chia-Yu CY   Liu Chiao-Rou CR   Hung Chu-Mi CM   Huang Chun-Chueh CC   Liu Hao-Ping HP   Wu Chih-Ching CC  

Cellular & molecular biology letters 20241107 1

<h4>Background</h4>Oral cancer accounts for 2% of cancer-related deaths globally, with over 90% of cases being oral cavity squamous cell carcinomas (OSCCs). Approximately 50% of patients with OSCC succumb to the disease within 5 years, primarily due to the advanced stage at which it is typically diagnosed. This underscores an urgent need to identify proteins related to OSCC progression to develop effective diagnostic and therapeutic strategies.<h4>Methods</h4>To identify OSCC progression-related  ...[more]

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