Human Nek2A interactome analysis via TurboID
Ontology highlight
ABSTRACT:
INSTRUMENT(S):
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
SUBMITTER: 
Batuhan Mert Kalkan
LAB HEAD: CEYDA AÇILAN AYHAN
PROVIDER: PXD046867 | Pride | 2024-05-24
REPOSITORIES: Pride
Dataset's files
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Publications
Nek2A prevents centrosome clustering and induces cell death in cancer cells via KIF2C interaction.
Kalkan Batuhan Mert BM Ozcan Selahattin Can SC Cicek Enes E Gonen Mehmet M Acilan Ceyda C
Cell death & disease 20240316 3
Unlike normal cells, cancer cells frequently exhibit supernumerary centrosomes, leading to formation of multipolar spindles that can trigger cell death. Nevertheless, cancer cells with supernumerary centrosomes escape the deadly consequences of unequal segregation of genomic material by coalescing their centrosomes into two poles. This unique trait of cancer cells presents a promising target for cancer therapy, focusing on selectively attacking cells with supernumerary centrosomes. Nek2A is a ki ...[more]
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