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4D label-free quantitative proteome of mouse FGSCs

ABSTRACT: Identification of differentially expressed proteins following treatment of FGSCs.

INSTRUMENT(S): Orbitrap Exploris 480

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Cell Culture

SUBMITTER: Hong Zhou

LAB HEAD: Ji Wu

PROVIDER: PXD047216 | Pride | 2025-05-06

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	MS_identified_information.txt.zip	Txt
	XA05709LQ_Fyn1.raw	Raw
	XA05709LQ_Fyn2.raw	Raw
	XA05709LQ_Fyn3.raw	Raw
	XA05709LQ_NC1.raw	Raw

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1 - 5 of 8

Publications

Nicotinamide mononucleotide promotes female germline stem cell proliferation by activating the H4K16ac-Hmgb1-Fyn-PLD signaling pathway through epigenetic remodeling.

Zhou Hong H Liu Yujie Y Tian Geng G GG Wu Ji J

Cell & bioscience 20250417 1

<h4>Background</h4>Nicotinamide mononucleotide (NMN), an endogenous nucleotide essential for various physiological processes, has an unclear role and regulatory mechanisms in female germline stem cell (FGSC) development.<h4>Results</h4>We demonstrate that NMN significantly enhances FGSC viability and proliferation. Quantitative acetylation proteomics revealed that NMN markedly increases the acetylation of histone H4 at lysine 16 (H4K16ac). Subsequent chromatin immunoprecipitation sequencing (ChI ...[more]

PMID: 40247362

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