Dataset Information

Impact of Cerium Oxide Nanoparticles on Rat Myoblast Proteome

ABSTRACT: Oxidative stress is a widespread causative agent of disease. Together with its general relevance for biomedicine, such dynamic is recognizably detrimental to space exploration. Among other solutions, cerium oxide nanoparticles (or nanoceria, NC) display a long-lasting, self-renewable antioxidant activity. In a previous experiment, we evaluated oxidative imbalance in rat myoblasts in space – aboard the International Space Station –, and unveiled possible protective effects from NC through RNA sequencing. Here we focus on myoblast response to NC on land by means of proteomics, defining a list of proteins that putatively react to NC and confirming nucleosomes/histones as likely mediators of its molecular action.

INSTRUMENT(S):

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Early Embryonic Cell

SUBMITTER: Andrea Armirotti

LAB HEAD: Andrea Armirotti

PROVIDER: PXD047391 | Pride | 2025-06-09

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	CB_19Feb2019_NANOROS_Sample1.wiff	Wiff
	CB_19Feb2019_NANOROS_Sample1.wiff.scan	Wiff
	CB_19Feb2019_NANOROS_Sample2.wiff	Wiff
	CB_19Feb2019_NANOROS_Sample2.wiff.scan	Wiff
	CB_19Feb2019_NANOROS_Sample3.wiff	Wiff

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Publications

Proteome Alterations and Nucleosome Activation in Rat Myoblasts Treated with Cerium Oxide Nanoparticles.

Degl'Innocenti Andrea A Braccia Clarissa C Genchi Giada Graziana GG di Leo Nicoletta N Leoncino Luca L Catalano Federico F Armirotti Andrea A Ciofani Gianni G

ACS omega 20240627 27

Oxidative stress is a widespread causative agent of disease. Together with its general relevance for biomedicine, such a dynamic is recognizably detrimental to space exploration. Among other solutions, cerium oxide nanoparticles (or <i>nanoceria</i>, NC) display a long-lasting, self-renewable antioxidant activity. In a previous experiment, we evaluated oxidative imbalance in rat myoblasts in space, aboard the International Space Station, and unveiled possible protective effects from NC through R ...[more]

PMID: 39005815

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