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Bioactive decellularized extracellular matrix-based hydrogel supports human adipose tissue-derived stem cell maintenance and fibrocartilage phenotype

ABSTRACT: Decellularized extracellular matrix (dECM)-based hydrogels combined with hASCs could serve as an interface for studying behavior and differentiation properties in a cartilage microenvironment. In the present study, we described the behavior of hASCs cultured in a commercial dECM MatriXpec™. The protein composition of MatriXpec™ was accessed by mass spectrometry and is mainly represented by collagen proteins, building an hydrogel fibrous ultrastructure.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Sus Scrofa Domesticus (domestic Pig)

TISSUE(S): Chondrocyte, Tendon

DISEASE(S): Cartilage Disease

SUBMITTER: Marco Augusto Stimamiglio

LAB HEAD: Marco Augusto Stimamiglio

PROVIDER: PXD047464 | Pride | 2023-12-22

REPOSITORIES: Pride

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