Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Enrique Calvo
LAB HEAD: Enrique Calvo
PROVIDER: PXD047527 | Pride | 2024-01-26
REPOSITORIES: Pride
Curtabbi Andrea A Guarás Adela A Cabrera-Alarcón José Luis JL Rivero Maribel M Calvo Enrique E Rosa-Moreno Marina M Vázquez Jesús J Medina Milagros M Enríquez José Antonio JA
Redox biology 20231220
Respiratory complex I plays a crucial role in the mitochondrial electron transport chain and shows promise as a therapeutic target for various human diseases. While most studies focus on inhibiting complex I at the Q-site, little is known about inhibitors targeting other sites within the complex. In this study, we demonstrate that diphenyleneiodonium (DPI), a N-site inhibitor, uniquely affects the stability of complex I by reacting with its flavin cofactor FMN. Treatment with DPI blocks the fina ...[more]