Dataset Information
Zimmerman and Counter TurboID of rhabdomyosarcoma fusion proteins.
Ontology highlight
ABSTRACT:
INSTRUMENT(S):
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Brain, Cotyledon, Cell Suspension Culture, Cerebrospinal Fluid, Blood Serum, Cell Culture, Colon, Bone Marrow
SUBMITTER: 
Erik Soderblom
LAB HEAD: Christopher Counter
PROVIDER: PXD047630 | Pride | 2026-03-26
REPOSITORIES: Pride
Dataset's files
Items per page: 1 - 5 of 28 |
Publications
Fusion-positive rhabdomyosarcoma oncofusions share a common interactome.
Nature communications 20260528
Fusion-positive rhabdomyosarcoma (FP-RMS) arises from at least seven distinct oncofusions sharing a common PAX3/7 N-terminal DNA-binding domain fused to divergent C-terminal partners. How different oncofusions produce the same cancer was unknown. Here we show they are functionally interchangeable, associate with a shared protein network we term the common interactome, bind overlapping target genes, and drive a similar core transcriptional program. The common interactome contains the C-terminal p ...[more]