Proteomics

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Unraveling the Interplay of Sustained Caloric Restriction and Adipose Tissue GLUT4 Translocation in Insulin Sensitivity Regulation

ABSTRACT: Caloric restriction (CR) is a well-established dietary strategy known to enhance insulin sensitivity and mitigate the risk of metabolic disorders. Despite its proven benefits, the precise molecular mechanisms underlying CR's positive impacts remain incompletely elucidated. Therefore, the principal goal of this study was to identify specific proteins and pathways involved in the enhancements of insulin sensitivity attributed to sustained caloric restriction.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture, Fat Cell, Adipose Tissue

SUBMITTER: Carmen Merali  

LAB HEAD: Salim Merali, Ph.D.

PROVIDER: PXD047731 | Pride | 2025-05-06

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
CALERIE_CR_vs_AL_baseline_and_12M.mzML Mzml
CALERIE_CR_vs_AL_baseline_and_12M.mzid.gz Mzid
CALERIE_CR_vs_AL_baseline_and_24M.mzML Mzml
CALERIE_CR_vs_AL_baseline_and_24M.mzid.gz Mzid
Control1_SCX1.raw Raw
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Publications

Sustained caloric restriction potentiates insulin action by activating prostacyclin synthase.

Merali Carmen C   Quinn Connor C   Huffman Kim M KM   Pieper Carl F CF   Bogan Jonathan S JS   Barrero Carlos A CA   Merali Salim S  

Obesity (Silver Spring, Md.) 20241017 12

<h4>Objective</h4>Caloric restriction (CR) is known to enhance insulin sensitivity and reduce the risk of metabolic disorders; however, its molecular mechanisms are not fully understood. This study aims to elucidate specific proteins and pathways responsible for these benefits.<h4>Methods</h4>We examined adipose tissue from participants in the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy Phase 2 (CALERIE 2) study, comparing proteomic profiles from individuals after  ...[more]

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