Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture, Fat Cell, Adipose Tissue
SUBMITTER: Carmen Merali
LAB HEAD: Salim Merali, Ph.D.
PROVIDER: PXD047731 | Pride | 2025-05-06
REPOSITORIES: Pride
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Obesity (Silver Spring, Md.) 20241017 12
<h4>Objective</h4>Caloric restriction (CR) is known to enhance insulin sensitivity and reduce the risk of metabolic disorders; however, its molecular mechanisms are not fully understood. This study aims to elucidate specific proteins and pathways responsible for these benefits.<h4>Methods</h4>We examined adipose tissue from participants in the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy Phase 2 (CALERIE 2) study, comparing proteomic profiles from individuals after ...[more]