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Response of malaria parasites to artemisin compounds and oxidative stress

ABSTRACT: Artemisin and its derivates are important antimalarials used for treatment of P. falciparum malaria. While the mode of action has been attributed to oxidative stress, methylation and unfolded protein response, the exact mechanism of action of these antimalarials is not known. Here, we used cellular thermal shift assay (CETSA) on live P. falcparum cultures to investigate the MOA of artemesinins using different artemisinin derivates (DHA, ART, AS, ATM and a control drug deoxyART) and different oxidative (di-amide and tert-BOOH) and reducing (DTT,NAC) agents.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human) Plasmodium Falciparum (isolate 3d7)

TISSUE(S): Erythrocyte, Blood

DISEASE(S): Plasmodium Falciparum Malaria

SUBMITTER: Samuel Pazicky

LAB HEAD: Zbynek Bozdech

PROVIDER: PXD047875 | Pride | 2025-05-22

REPOSITORIES: Pride

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			Action	DRS
	Artemether_InParasite_ITDR_37.msf	Msf
	Artemether_InParasite_ITDR_37.zip	Other
	Artemether_InParasite_ITDR_51.msf	Msf
	Artemether_InParasite_ITDR_51.zip	Other
	Artemether_InParasite_ITDR_57.msf	Msf

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