SARS-CoV-2 variants mediated tissue-specific metabolic reprogramming determines the disease pathophysiology in hamster model

ABSTRACT: Seeking a nuanced understanding of host tissue-specific responses and their implications for immunopathogenicity against the SARS-CoV-2 infection was convoluted and not evaluated earlier. We delved into the intricacies of using to understand the complex relationship among acute multi-tissue injury, dysbiosis of the gut microbiota, and the resulting implications for SARS-CoV-2 variant-specific immunopathogenesis in the Golden Syrian hamster (GSH) model. Our investigation revealed increased viremia in diverse tissues of delta-infected GSH compared to the Omicron variant. Multi-omics analyses uncovered distinctive metabolic responses between the delta and omicron variants, with the former demonstrating dysregulation in synaptic transmission proteins associated with neurological disorders. Additionally, delta-infected GSH exhibited an altered fecal microbiota composition, marked by increased inflammatory-associated taxa and reduced commensal bacteria compared to the omicron variant. These findings underscore the SARS-CoV-2-mediated tissue insult, characterized by modified host metabolites, neurological protein dysregulation, and acute gut dysbiosis, highlighting the compromised gut-lung-brain axis during acute infection.

INSTRUMENT(S):

ORGANISM(S): Mesocricetus Auratus (golden Hamster)

TISSUE(S): Brain

DISEASE(S): Covid-19

SUBMITTER: Akos Vegvari  

LAB HEAD: Akos Vegvari

PROVIDER: PXD048058 | Pride | 2026-01-05

REPOSITORIES: Pride