Identification of the protein targets of a small molecule

ABSTRACT: Mass spectrometry-based chemical proteomic approaches using limited proteolysis for analysis of the interactions between a small molecule and its protein target(s). DARTS (Drug Affinity Responsive Target Stability) has been used in this study on Hela cell lysate. Ubiquitin carboxyl-terminal hydrolase 5 (USP5) was identified as one of the targets of the studied small molecule.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture, Uterine Cervix

SUBMITTER: Gilda D'Urso  

LAB HEAD: Agostino Casapullo

PROVIDER: PXD048098 | Pride | 2024-01-15

REPOSITORIES: Pride