Rebound after MAPK inhibitor withdrawal in pLGG cells
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ABSTRACT: An in vitro MAPK inhibitor withdrawal rebound model was generated using the patient-derived, PXA-like cell line BT-40 (BRAFV600E, CDKN2Adel). Using this model, we investigated potential cellular intrinsic and extrinsic mechanisms involved in rebound growth in pLGG through multi-omics analysis (RNAseq, phospho-/proteomics).
INSTRUMENT(S): timsTOF Pro
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Malignant Cell, Cell Culture
DISEASE(S): Brain Cancer
SUBMITTER: Daniela Kocher
LAB HEAD: Romain Sigaud
PROVIDER: PXD048277 | Pride | 2024-04-17
REPOSITORIES: Pride
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