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FOLR1-interacting proteins in neurulating Xenopus laevis embryos

ABSTRACT: Identification of FOLR1-interacting proteins in Xenopus laevis embryos during neurulation.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Xenopus Laevis (african Clawed Frog)

SUBMITTER: Olga Balashova

LAB HEAD: Laura Noemi Borodinsky

PROVIDER: PXD048476 | Pride | 2024-02-26

REPOSITORIES: Pride

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Noncanonical function of folate through folate receptor 1 during neural tube formation.

Balashova Olga A OA Panoutsopoulos Alexios A AA Visina Olesya O Selhub Jacob J Knoepfler Paul S PS Borodinsky Laura N LN

Nature communications 20240222 1

Folate supplementation reduces the occurrence of neural tube defects (NTDs), birth defects consisting in the failure of the neural tube to form and close. The mechanisms underlying NTDs and their prevention by folate remain unclear. Here we show that folate receptor 1 (FOLR1) is necessary for the formation of neural tube-like structures in human-cell derived neural organoids. FOLR1 knockdown in neural organoids and in Xenopus laevis embryos leads to NTDs that are rescued by pteroate, a folate pr ...[more]

PMID: 38388461

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