Parallel genetic excisions of the cardiac troponin I N-terminal extension in tachycardic mammals

ABSTRACT: A study of cardiac troponin I evolution in mammals with high heart rates, including shrews, moles, and bats. With genomic, mRNA and protein level analyses we showed repeated loss of the N-terminal extension. Here, liquid chromatography with tandem mass spectrometry was used to verify cardiac troponin I (TNNI3) protein identity in ∼22 kDa bands from Pyrenean desman (Galemys pyrenaicus) and northern short-tailed shrew (Blarina brevicauda) hearts.

INSTRUMENT(S):

ORGANISM(S): Galemys Pyrenaicus Blarina Brevicauda

TISSUE(S): Heart

SUBMITTER: William Joyce  

LAB HEAD: Kevin L. Campbell

PROVIDER: PXD048600 | Pride | 2024-07-19

REPOSITORIES: Pride