Disulfide mapping of J-chain by crosslinking MS

ABSTRACT: Here we show how J-chain (JC) outcompetes the sixth IgM subunit during assembly. We looked at the disulfide re-arrangements in JC and showed that it exists as an unstructured protein with non-native disulfides before its insertion into IgM.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

SUBMITTER: Yevheniia Bushman  

LAB HEAD: Johannes Buchner

PROVIDER: PXD048614 | Pride | 2024-12-04

REPOSITORIES: Pride