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Quantitative proteinomics on WWP2 overexpressed human tubular epithelial cells HK-2

ABSTRACT: WWP2 is a E3 ligase which regulates multiple cellular events, such as stress response, differentiation. WWP2 played physiological role in the distal tubules of the kidneys. Whether WWP2 regulated pathophysiological rol in the proximal tubules is unclear. In the present study, we stably overexpressed WWP2 using lenti-viral infection in the human tubular epithelial cells, HK-2, and performed proteinomics analysis to explore WWP2's potential substrates.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: Ran You

LAB HEAD: Aihua Zhang

PROVIDER: PXD048622 | Pride | 2025-06-09

REPOSITORIES: Pride

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			Action	DRS
	ED141TQ_Fr1.raw	Raw
	ED141TQ_Fr2.raw	Raw
	ED141TQ_Fr3.raw	Raw
	ED141TQ_Fr4.raw	Raw
	ED141TQ_Fr5.raw	Raw

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Publications

WWP2 deletion aggravates acute kidney injury by targeting CDC20/autophagy axis.

You Ran R Li Yanwei Y Jiang Yuteng Y Hu Dandan D Gu Menglei M Zhou Wei W Zhang Shengnan S Bai Mi M Yang Yunwen Y Zhang Yue Y Huang Songming S Jia Zhanjun Z Zhang Aihua A

Journal of advanced research 20240622

<h4>Introduction</h4>Acute kidney injury (AKI) is associated with high morbidity and mortality rates. The molecular mechanisms underlying AKI are currently being extensively investigated. WWP2 is an E3 ligase that regulates cell proliferation and differentiation. Whether WWP2 plays a regulatory role in AKI remains to be elucidated.<h4>Objectives</h4>We aimed to investigate the implication of WWP2 in AKI and its underlying mechanism in the present study.<h4>Methods</h4>We utilized renal tissues f ...[more]

PMID: 38909885

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