Effect of type I and type II kinase inhibitors on the LRRK2 proximity proteome

ABSTRACT: Type I and type II inhibitors have been demonstrated to stabilize LRRK2 either in an active or inactive kinase conformation. Furthermore, one type I inhibitors show a marked reduction in LRRK2 N-terminal phosphorylation on Serine 910 and 935. In this study, we generated comparative proximity proteomes upon treatment of HEK293 cells stably expressing miniTurbo(mT)-LRRK2 with either the LRRK2 specific type I inhibitor MLi-2 or the type inhibitor GZD-824 previously shown to inhibit LRRK2 at the used concentration.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Christian Johannes Gloeckner  

LAB HEAD: Christian Johannes Gloeckner

PROVIDER: PXD048806 | Pride | 2026-05-19

REPOSITORIES: Pride