Dataset Information

Identification of RNA Pol II polymerase interactome in ALL cells

ABSTRACT: RNA polymerase II is a protein encoded by the POLR2A gene in humans. In coordination with a wide array of interacting partners, RNA polymerase II has been shown to participate in the regulation of the cell cycle, transcription, and splicing, all of which are important for ALL growth. Here, we investigated the RNA Pol II polymerase interactome, focusing on the splicing-related apparatus to identify the splicing factors involved in co-transcriptional splicing, which is important for ALL cell growth.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): B Cell

DISEASE(S): Acute Leukemia

SUBMITTER: Vishwajeeth Pagala

LAB HEAD: Dr. John Crispino

PROVIDER: PXD048846 | Pride | 2025-05-06

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	Crispigrp_032223_N6RPB1IgG_B1.1.pepXML	Pepxml
	Crispigrp_032223_N6RPB1IgG_B1.mzXML	Mzxml
	Crispigrp_032223_N6RPB1IgG_B1.raw	Raw
	Crispigrp_032223_N6RPB1IgG_B2.1.pepXML	Pepxml
	Crispigrp_032223_N6RPB1IgG_B2.mzXML	Mzxml

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1 - 5 of 15

Publications

Disruption of cotranscriptional splicing suggests RBM39 is a therapeutic target in acute lymphoblastic leukemia.

Jin Qi Q Harris Ethan E Myers Jacquelyn A JA Mehmood Rashid R Cotton Anitria A Shirnekhi Hazheen K HK Baggett David W DW Wen Jeremy Qiang JQ Schild Andrew B AB Bhansali Rahul S RS Klein Jonathon J Narina Shilpa S Pieters Tim T Yoshimi Akihide A Pruett-Miller Shondra M SM Kriwacki Richard R Abdel-Wahab Omar O Malinge Sebastien S Ntziachristos Panagiotis P Obeng Esther A EA Crispino John D JD

Blood 20241201 23

<h4>Abstract</h4>There are only a few options for patients with relapsed/refractory B-cell acute lymphoblastic leukemia (B-ALL), thus, this is a major area of unmet medical need. In this study, we reveal that the inclusion of a poison exon in RBM39, which could be induced by both CDK9 or CDK9 independent cyclin-dependent kinases, mitogen-activated protein kinases, glycogen synthase kinases, CDC-like kinases (CMGC) kinase inhibition, is recognized by the nonsense-mediated messenger RNA decay path ...[more]

PMID: 39316649

Dataset Information

Identification of RNA Pol II polymerase interactome in ALL cells

Dataset's files

Publications

Disruption of cotranscriptional splicing suggests RBM39 is a therapeutic target in acute lymphoblastic leukemia.

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