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Sex-Dependent effects of Sortilin antisense oligonucleotide on Ldlr-/- mice

ABSTRACT: We evaluated the therapeutic potential of silencing sortilin expression in vivo using antisense oligonucleotide (ASO-Sort1) to reduce atherosclerosis and associated calcification. Male and female Ldl (low-density lipoprotein) receptor deficient mice were fed a high-fat diet and treated with ASO-Sort1 for 15 weeks.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Aortic Arch

SUBMITTER: Adrien Lupieri

LAB HEAD: Dr Elena

PROVIDER: PXD048883 | Pride | 2026-06-15

REPOSITORIES: pride

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			Action	DRS
	12_DBG_ASO_SORT1_Mice_AorticArch.mzML	Mzml
	12_DBG_ASO_SORT1_Mice_AorticArch.mzid.gz	Mzid
	12_DBG_ASO_SORT1_Mice_AorticArch.pdResult	Other
	12_DBG_F_AoArch_Control_F1107dTopS_CID-IT_90min.raw	Raw
	12_DBG_F_AoArch_Control_F1207dTopS_CID-IT_90min.raw	Raw

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Publications

Antisense Oligonucleotide Targeting Sortilin Reduces Vascular Calcification in Mice in a Sex-Dependent Manner.

Lupieri Adrien A Becker-Greene Dakota D Le Thanh-Dat TD Roschel Marina M MM Jha Prabhash K PK Sonawane Abhijeet R AR Mullick Adam A Tsimikas Sotirios S Kuraoka Shiori S Singh Sasha A SA Aikawa Masanori M Aikawa Elena E

Arteriosclerosis, thrombosis, and vascular biology 20250612 8

<h4>Background</h4>Atherosclerotic calcification is a complex pathological process associated with an increased risk of cardiovascular events. Despite extensive research, this disorder has no effective therapeutic strategies. In this study, we evaluated the therapeutic potential of silencing Sort (sortilin) expression in vivo using antisense oligonucleotide (ASO-Sort1) to reduce the development of atherosclerosis and associated calcification.<h4>Methods</h4>Male and female <i>Ldlr</i><sup>-/-</s ...[more]

PMID: 40501380

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