Proteomics

Dataset Information

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Ancient tooth enamel proteomes to help understand post mortem protein degradation over millions of years

ABSTRACT: The tooth enamel proteome is enzymatically broken down during development, which leads to a heterogenous distribution of remaining peptides of a protein sequence in a grown individual's enamelome. After death of the organism, the heterogeneous distribution of remaining peptides may be enhanced, as the proteome further degrades. The pattern of this degradation is poorly understood, but it might happen at different rates depending on the site within the protein sequence, due to different chemical properties of the peptides and their interaction with the environment. To learn more about this process, we recovered six ancient enamel proteomes from Equidae and Proboscidea fossils from Spain. The fossils span an age range of <100 ka to 11.6 Ma.

INSTRUMENT(S): Orbitrap Eclipse

ORGANISM(S): Equidae Proboscidea <placentals>

TISSUE(S): Tooth Enamel

SUBMITTER: Johanna Krueger  

LAB HEAD: Tomas Marques-Bonet

PROVIDER: PXD048972 | Pride | 2025-05-06

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
Deinotherium_giganteum_IPS28029.raw Raw
Deinotherium_giganteum_IPS28029_txt_MQ_2.0.2.0.zip Other
Deinotherium_levis_IPS121827.raw Raw
Deinotherium_levius_IPS121827_txt_MQ2.0.2.0.zip Other
Equus_cf_altidens_IPS137786.raw Raw
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Publications

Ancient tooth enamel, and to some extent dentin and bone, contain characteristic peptides that persist for long periods of time. In particular, peptides from the enamel proteome (enamelome) have been used to reconstruct the phylogenetic relationships of fossil taxa. However, the enamelome is based on only about 10 genes, whose protein products undergo fragmentation in vivo and post mortem. This raises the question as to whether the enamelome alone provides enough information for reliable phyloge  ...[more]

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