Dataset Information

Hays_Eroglu Label Free in vivo BioID

ABSTRACT: To use in vivo proximity labeling to identify molecular interactors of the intracellular domain of the Neuroligin family of cell adhesion molecules in astrocytes and neurons, two major cell types of the central nervous system

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

SUBMITTER: Erik Soderblom

LAB HEAD: Cagla Eroglu, PhD

PROVIDER: PXD049185 | Pride | 2026-06-29

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	ID49272_01_FSN20560_5460_101819.raw	Raw
	ID49273_01_FSN20560_5460_101819.raw	Raw
	ID49274_01_FSN20560_5460_101819.raw	Raw
	ID49275_01_FSN20560_5460_101819.raw	Raw
	ID49276_01_FSN20560_5460_101819.raw	Raw

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Publications

Neuroligin-2 is ubiquitinated by Nedd4l to control developmental astrocyte morphogenesis.

Sakers Kristina K Ramirez Juan J JJ Elazar Nimrod N Nagendren Leykashree L Soderblom Erik E Eroglu Cagla C

The Journal of cell biology 20260601 7

Central nervous system astrocytes have an intricate, highly branched morphology. Proper development of perisynaptic astrocyte processes is necessary for tripartite synapse formation and function. However, cellular pathways orchestrating this development are largely unknown. Neuroligins (NLs) 1-3 regulate astrocyte morphogenesis via transcellular adhesions with neuronal neurexins. Here, we found an astrocytic NL2-based mechanism governing morphogenesis. Through structure and function studies, we ...[more]

PMID: 42223381

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