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Mule milk as an alternative to donkey milk for the nutrition of allergic infants

ABSTRACT: Cow milk is a widespread food, but several children are allergic to it – chiefly because of adverse reactions to its proteins. Nutritionally valid, hypoallergenic surrogates are highly sought after, and among them donkey milk is prized for its tolerability and human-like composition. Still, donkeys produce very little milk, with disastrous consequences for marketability and supply chain. Mules are crosses between a donkey stallion and a horse mare, and female ones can be set pregnant via embryo transfer for later lactation, conceivably within economically sustainable production strategies. Owing to their bigger average body size, mules should produce more milk than donkeys, yet the protein profile and allergenicity of mule milk are vastly unknown. Here we present a proteomics characterization of mule milk, obtained via a mule-in-mule surrogate gestation. Through experiments on blood sera from allergic children, we show that such milk is less allergenic than its cattle analog, possibly being at some advantage even with respect to donkey milk.

INSTRUMENT(S):

ORGANISM(S): Equus Caballus (horse) Equus Asinus Asinus

TISSUE(S): Milk

SUBMITTER: Martina Bartolucci

LAB HEAD: Andrea Petretto

PROVIDER: PXD049331 | Pride | 2026-07-16

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	20231110_115246_Latte_di_Mula.sne	Other
	Deglinnocenti_latte_asina_LA_3A_35.raw	Raw
	Deglinnocenti_latte_asina_LA_3B_36.raw	Raw
	Deglinnocenti_latte_asina_LA_3C_37.raw	Raw
	Deglinnocenti_latte_mula_3gg_A_15.raw	Raw

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