Dataset Information

The human milk oligosaccharide 2’-fucosyllactose protects against high-fat diet induced obesity by changing intestinal mucus production, composition and degradation linked to changes in gut microbiota and fecal proteome profiles in mice

ABSTRACT: The aim of this study was to decipher the mechanisms by which the major human milk oligosaccharide (HMO), 2’-fucosyllactose (2’FL), can affect body weight and fat mass gain upon high-fat diet (HFD) feeding in mice. In particular, we wanted to elucidate whether 2’FL metabolic effects are linked with changes in intestinal mucus production and secretion, mucin glycosylation and degradation, as well as with the modulation of the gut microbiota, fecal proteome and endocannabinoid (eCB) system.

INSTRUMENT(S):

ORGANISM(S): Bacteria Mus Musculus (mouse)

TISSUE(S): Feces

DISEASE(S): Obesity,Type 2 Diabetes Mellitus

SUBMITTER: Paola Paone

LAB HEAD: Patrice D. Cani

PROVIDER: PXD049406 | Pride | 2025-05-06

REPOSITORIES: Pride

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Human milk oligosaccharide 2'-fucosyllactose protects against high-fat diet-induced obesity by changing intestinal mucus production, composition and degradation linked to changes in gut microbiota and faecal proteome profiles in mice.

Paone Paola P Latousakis Dimitris D Terrasi Romano R Vertommen Didier D Jian Ching C Borlandelli Valentina V Suriano Francesco F Johansson Malin E V MEV Puel Anthony A Bouzin Caroline C Delzenne Nathalie M NM Salonen Anne A Juge Nathalie N Florea Bogdan I BI Muccioli Giulio G GG Overkleeft Herman H Van Hul Matthias M Cani Patrice D PD

Gut 20240909 10

<h4>Objective</h4>To decipher the mechanisms by which the major human milk oligosaccharide (HMO), 2'-fucosyllactose (2'FL), can affect body weight and fat mass gain on high-fat diet (HFD) feeding in mice. We wanted to elucidate whether 2'FL metabolic effects are linked with changes in intestinal mucus production and secretion, mucin glycosylation and degradation, as well as with the modulation of the gut microbiota, faecal proteome and endocannabinoid (eCB) system.<h4>Results</h4>2'FL supplement ...[more]

PMID: 38740509

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