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Healthy aging of skeletal muscle: Insights from a combined morphological and multiomic study

ABSTRACT: Aging impacts on the plasticity and biochemistry of skeletal muscle. For a deeper understanding of skeletal muscle function in aging and sarcopenia, defined as age related muscle decline, the identification of molecular signatures regulating muscle function under physiological conditions is important. While molecular studies of healthy skeletal muscle in humans were performed in adults and older subjects, skeletal muscle from infants are poorly investigated in terms of combined morphological, transcriptomic and proteomic profiles.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Skeletal Muscle

SUBMITTER: Andreas Hentschel

LAB HEAD: Andreas Hentschel

PROVIDER: PXD049424 | Pride | 2025-05-06

REPOSITORIES: pride

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			Action	DRS
	F025088.dat	Other
	F025097.dat	Other
	F025109.dat	Other
	F025116.dat	Other
	F025121.dat	Other

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Publications

Molecular composition of skeletal muscle in infants and adults: a comparative proteomic and transcriptomic study.

Schaiter Alexander A Hentschel Andreas A Kleefeld Felix F Schuld Julia J Umathum Vincent V Procida-Kowalski Tara T Nelke Christopher C Roth Angela A Hahn Andreas A Krämer Heidrun H HH Ruck Tobias T Horvath Rita R van der Ven Peter F M PFM Bartkuhn Marek M Roos Andreas A Schänzer Anne A

Scientific reports 20241003 1

To gain a deeper understanding of skeletal muscle function in younger age and aging in elderly, identification of molecular signatures regulating these functions under physiological conditions is needed. Although molecular studies of healthy muscle have been conducted on adults and older subjects, there is a lack of research on infant muscle in terms of combined morphological, transcriptomic and proteomic profiles. To address this gap of knowledge, we performed RNA sequencing (RNA-seq), tandem m ...[more]

PMID: 39362957

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