Proteomics

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Urinary glycopeptide profile differentiates early cardiorenal risk in subjects not meeting criteria for chronic kidney disease

ABSTRACT: Early diagnosis and treatment of chronic kidney disease (CKD) is a worldwide challenge. Albuminuria is defined as urinary albumin:creatinine ratio (ACR) ≥30 mg/g. Subjects with ACR values below this cut-off and preserved renal function are considered at no cardiorenal risk, but increased risk is established even at the 10-30 mg/g ACR range, supporting the need to identify other molecular indicators for early assessment of normoalbuminuric patients at higher risk. Following our previous studies, here we aimed to stratify the normoalbuminuria range according to cardiorenal risk and identify glycoproteins and N-glycosylation sites associated to kidney damage in subclinical CKD.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Urine

DISEASE(S): Chronic Kidney Disease

SUBMITTER: Juan A Lopez  

LAB HEAD: Juan A Lopez

PROVIDER: PXD049688 | Pride | 2025-06-02

REPOSITORIES: Pride

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JAL_Ara_Glyco_Mix1.msf Msf
JAL_Ara_Glyco_Mix1.raw Raw
JAL_Ara_Glyco_Mix2.msf Msf
JAL_Ara_Glyco_Mix2.raw Raw
JAL_Ara_Mix1_aliq.msf Msf
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Publications

Early diagnosis and treatment of chronic kidney disease (CKD) is a worldwide challenge. Subjects with albumin-to-creatinine ratio (ACR) ≥ 30 mg/g and preserved renal function are considered to be at no cardiorenal risk in clinical practice, but prospective clinical studies evidence increased risk, even at the high-normal (HN) ACR range (10-30 mg/g), supporting the need to identify other molecular indicators for early assessment of patients at higher risk. Following our previous studies, here we  ...[more]

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